Diurnal rhythm of urinary carnitine excretion in healthy adults

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Carnitine -- Excretion., Creatinine -- Excretion., Circadian rhy
Statementby Monika Merbecks.
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Open LibraryOL14705139M

To our knowledge, only two previous studies have examined diurnal variation of albumin excretion in healthy subjects, both showing lower excretion in ON samples [17, 18].

The reason for this difference may include daytime erect position (postural proteinuria) or physical exercise [ Cited by: 4.

Description Diurnal rhythm of urinary carnitine excretion in healthy adults PDF

The urinary excretion of Total and Free l-carnitine was significantly higher in hypertensive adolescents in comparison to reference group—white coat hypertension. Other important findings were positive correlations between Free l -carnitine/cr., Total l -carnitine/cr. ratio and serum uric acid level, serum cholesterol level and systolic blood by: 1.

Chalmers RA, Roe CR, Stacey TE, et al: Urinary excretion of l- carnitine and acylcarnitines by patients with disorders of organic acid metabolism: evidence for secondary insufficiency of l-carnitine.

Ped Res ; 2. Urinary excretion of total carnitine increased by a factor of 10 during cisplatin administration and also normalized 7 days after cessation of chemotherapy.

This increase was due to excretion of both free carnitine and acylcarnitine and averaged approximately 1 mmol carnitine per by: normal daily urinary excretion of total carnitine is only imol (4), excess dietary carnitine must be destroyed by in-digenous gut flora (6), stored, or utilized.

The potential influence of diet on excretion is evident. Early studies on urinary excretion of carnitine generally ig-nored diet (7). This may be because the carnitine content ofCited by: The urine excretion of L-carnitine (LC), acetyl-L-carnitine (ALC) and propionyl-Lcarnitine (PLC) and their relations with the antioxidant activities are presently unknown.

Liquid L-carnitine ( g) was administered orally as a single dose in 12 healthy subjects. Urine concentrations of LC, ALC and PLC were detected by HPLC.

“Primary” Carnitine Deficiencies in Children Charles A. Stanley, MD Endocrine Division Children’s Hospital of Philadelphia. • Adults on vegetarian diet (no carnitine) – plasma carnitine normal – urinary carnitine excretion reduced (25% ofFile Size: KB.

Diurnal or circadian variations in urine volume, electrolyte excretion, uroflow, micturition frequency, volume per void, and urine and osmole output rates have been extensively Diurnal rhythm of urinary carnitine excretion in healthy adults book [].

Details Diurnal rhythm of urinary carnitine excretion in healthy adults EPUB

For example, water and electrolyte excretion is significantly low during the sleep phase compared with active daytime in healthy control subjects but not in patients with congestive heart Cited by:   ABSTRACT: Reduced plasma and tissue concentrations of carnitine, a cofactor required for fatty acid oxidation, are present in patients with inherited Cited by: removal is probably comparable to normal urinary excretion, free carnitine clearance by hemodialysis is greater than that of acylcarnitine.

This pattern is the reverse of normal urinary carnitine excretion. • Fatty acid metabolism is impaired in renal failure. Thus, incompletely metabolized acyl residues accumulate and drive the formation of. Urinary calcium excretion is influenced by many factors, but the literature is not sufficient regarding the diurnal rhythm.

We aimed to investigate diurnal rhythm of calcium excretion in a healthy adult population. MATERIAL AND METHOD Forty healthy individuals (30 male, 10 female; mean ages of ± and ± respectively) were. Urinary free cortisol and cortisone concentrations showed a significant normal diurnal rhythm, but levels were lower across the cycle in CFS.

In addition, we report novel effects of sleep deprivation on several urinary metabolites, particularly formate, 3-indoxyl sulfate, carnitine and taurine. Improving our understanding of how the metabolome is influenced by circadian rhythms, time of day variation, and sleep patterns is critical for a more accurate interpretation of the relationships between the exposome, metabolome and risk of Cited by: INTRODUCTION.

L-carnitine (3-hydroxyN-trimethylammonium butyrate, LC) is an endogenous compound which has several physiological is involved in the transfer of long-chain fatty acids across the inner matrix membrane of mitochondria (Mancinelli et al., ).

It also regulates acetyl storage and transfer in mitochondria, cells, and between organs, and the transport of potentially. Chalmers, R., Roe, C., Stacey, T. et al. Urinary Excretion of l-Carnitine and Acylcarnitines by Patients with Disorders of Organic Acid Metabolism: Evidence for Secondary Insufficiency of by: Diurnal levels of urinary cortisol.

In this study, we found lower levels of urinary free cortisol throughout the course of the day in patients with CFS, but with unchanged diurnal rhythm. These findings are consistent with and add weight to the previous literature showing reduced urinary free cortisol in CFS. Furthermore, our findings have shown this reduction in urinary free cortisol at Cited by: Variations in the urinary excretion of arylsulphatase A, β-galactosidase, α-glucosidase and β-glucuronidase throughout a h period were studied in 8 Cited by:   The urinary excretion of Total and Free l-carnitine was significantly higher in hypertensive adolescents in comparison to reference group—white coat hypertension.

Other important findings were positive correlations between Free l -carnitine/cr., Total l -carnitine/cr. ratio and serum uric acid level, serum cholesterol level and systolic blood Cited by: 1. An assay for evaluating carnitine levels in normal children and adults is described.

After a 12‐hour period of fasting, individual variations in 24‐hour urinary excretion of carnitine were observed in adults.

In children, there was a significant decrease in excretion from the 10th month to the third year, and then an increase until the 10th Cited by: The healthy adult receiving no exogenous carnitine appears to be able to synthesize adequate endogenous carnitine, but this is less clear for infants and children and for the elderly.

5 x 5 Reuter, S.E., Evans, A.M., Chace, D.H. et al. Determination of the reference range of endogenous plasma carnitines in healthy by: Interestingly, the circadian rhythm of urinary AVP excretion showed higher values during the daytime ( ± ng/mmol creatinine, compared to ± ng/mmol creatinine, p Cited by: The diurnal rhythms of melatonin, cortisol, and testosterone were all affected differently by an increasing number of consecutive night shifts: the amplitude of the melatonin rhythm was suppressed.

The urinary excretion of 2Py and N1-MN was measured in a cross-sectional cohort of RTR and healthy kidney donors with liquid chromatography-tandem mass spectrometry (LC-MS/MS). Those patients with daily creatinine excretion carnitine excretion ( ± 47 versus ± 95 µmol/day, p excretion and carnitine excretion (r = ) and between muscle carnitine and carnitine excretion (r = ).

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Urinary clearances for Cited by: Life Sciences Vol. 20, pp. Pergamon Press Printed in the U.S.A. URINARY MELATONIN RHYTHMS DURING SLEEP DEPRIVATION IN DEPRESSED PATIENTS AND NORMALS David C.

Jimerson, M.D.,* Harry J. Lynch, Ph.D.,** Robert M. Post, M.D.,* Richard J. Wurtman, M.D.,** William E. Bunney, Jr., M.D.* *Section on Psychobiology, Adult Psychiatry Branch National Institute of Mental Health Cited by: can occur when the body is stressed.

In humans urinary potassium excretion peaks in the early morning between and with a minimum at night from to Therefore, the diurnal rhythm of urinary potassium excretion seems to be controlled by the diurnal rhythm of cortisol and/or aldosterone.

Not so for blood Size: KB. To investigate diurnal variations of these RNA catabolites, the amounts of psi, m(2)(2)G and t(6)A excreted were determined by HPLC of the urine from eight healthy male adults collected over h.

Acute effect of late evening meal on diurnal variation of blood glucose and energy metabolism. were calculated from V ˙ ⁡ O 2, V ˙ C O 2 and h urinary nitrogen excretion. Diurnal rhythm of motor activity and autonomic nervous system activity.

Motor activity (counts/min) was estimated using a wrist watch-like device, by:   L-CARNITINE IS A quaternary amine (β-hydroxy-γ- trimethylammonium butyrate) that is ubiquitous in biological fluids and tissues of mammals, where it plays an important role in energy metabolism (1–4).Primary and secondary deficiencies of carnitine, including the depletion of cardiac carnitine associated to coronary heart disease and heart failure, are the therapeutic indications for Cited by: Carnitine levels are disturbed in primary disorders of the carnitine cycle, or secondary disturbances of carnitine metabolism due to other biochemical disorders.

While plasma or serum carnitine is reduced in primary carnitine deficiency, urine carnitine may be normal or elevated. Carnitine concentrations are variably low in some tissues of vitamin C-deficient guinea pigs (Rebouche, ).

Choline has also been shown to affect carnitine homeostasis in humans and guinea pigs (Daily and Sachan, ). Choline supplementation resulted in decreased urinary excretion of carnitine in young adult women.The relationship of random urinary porphyrin and creatinine values as functions of age and sex was examined in a normal population.

Total urinary porphyrin was measured by a solvent extraction technique, while urinary creatinine was evaluated by an alkaline picrate method.

Random urine specimens from healthy patients (81 children and 39 adults) were by: when the body is stressed. In humans urinary potassium excretion peaks in the early morning between and with a minimum at night from to Therefore, the diurnal rhythm of urinary potassium excretion seems to be controlled by the diurnal rhythm of cortisol and/or aldosterone.

Not so for blood potassium.